Expression, production, and renaturation of a functional single-chain variable antibody fragment (scFv) against human ICAM-1
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چکیده
منابع مشابه
Expression, production, and renaturation of a functional single-chain variable antibody fragment (scFv) against human ICAM-1
Intercellular adhesion molecule-1 (ICAM-1) is an important factor in the progression of inflammatory responses in vivo. To develop a new anti-inflammatory drug to block the biological activity of ICAM-1, we produced a monoclonal antibody (Ka=4.19 × 10(-8) M) against human ICAM-1. The anti-ICAM-1 single-chain variable antibody fragment (scFv) was expressed at a high level as inclusion bodies in ...
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ژورنال
عنوان ژورنال: Brazilian Journal of Medical and Biological Research
سال: 2014
ISSN: 1414-431X,0100-879X
DOI: 10.1590/1414-431x20143276